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Depew is considered a Large Town with a population of 15,193 and 2,085 businesses. 27 in 2018 were added to the Depew Chamber of Commerce business directory which was more than 2017 which had 22.

The economy of Depew employs 10,362 people and has an unemployment rate of 5.1%. Some of the largest industries in Depew are Professional Services (124),Restaurants (98), and Builders & Contractors (40).

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