Keene is considered a Large Town with a population of 22,068 and 2,845 businesses. 20 in 2018 were added to the Keene Chamber of Commerce business directory which was less than 2017 which had 25.

The economy of Keene employs 14,035 people and has an unemployment rate of 4.2%. Some of the largest industries in Keene are Professional Services (183),Restaurants (76), and Entertainment Agencies & Bureaus (67).