Book now at the Comfort Suites St Charles-St Louis hotel in Saint Charles, MO. This pet-friendly Saint Charles hotel is conveniently located near Ameristar Casino, Historic Main Street St. Charles, St. Charles Convention Center, and Hollywood Casino Amphitheatre. Amenities include free WiFi, free hot breakfast, free parking, an indoor heated pool, and a fitness center. All guest rooms feature microwaves and refrigerators, USB ports, premium bedding, coffeemakers, and flat-panel TVs. Whether traveling to the Saint Charles area for business or leisure, the Comfort Suites St Charles-St Louis hotel has everything you need. Book today!