Kalamazoo is considered a Medium City with a population of 214,083 and 13,485 businesses. 109 in 2018 were added to the Kalamazoo Chamber of Commerce business directory which was less than 2017 which had 125.

The economy of Kalamazoo employs 139,582 people and has an unemployment rate of 8.8%. Some of the largest industries in Kalamazoo are Professional Services (856),Restaurants (425), and Entertainment Agencies & Bureaus (393).