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Clio is considered a Small Town with a population of 2,509 and 1,699 businesses. 12 in 2018 were added to the Clio Chamber of Commerce business directory which was less than 2017 which had 13.

The economy of Clio employs 1,272 people and has an unemployment rate of 14%. Some of the largest industries in Clio are Professional Services (213),Builders & Contractors (73), and Entertainment Agencies & Bureaus (39).
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