Muscatine is considered a Large Town with a population of 26,335 and 2,480 businesses. 14 in 2018 were added to the Muscatine Chamber of Commerce business directory which was less than 2017 which had 39.

The economy of Muscatine employs 17,460 people and has an unemployment rate of 3.5%. Some of the largest industries in Muscatine are Professional Services (182),Entertainment Agencies & Bureaus (101), and Restaurants (85).