Littleton is considered a Large Town with a population of 47,734 and 21,255 businesses. 281 in 2018 were added to the Littleton Chamber of Commerce business directory which was more than 2017 which had 280.

The economy of Littleton employs 33,223 people and has an unemployment rate of 4.3%. Some of the largest industries in Littleton are Professional Services (2,266),Locksmiths (975), and Personal Services & Consultants (787).